The overall aim of this thesis was to elucidate the mechanisms controlling contractility of the ureter. Functional organ bath studies with isolated porcine ureteral tissues were used to examine key systems involved in ureteral smooth muscle contraction. The findings demonstrate that G-protein coupled receptor-mediated contractile responses of ureteral tissues in response to muscarinic receptor, α1-adrenoceptor and 5-HT receptor stimulation differ with age and the latter two appear to play more dominant roles in mediation of ureteral smooth muscle contraction.
Year Manuscript Completed
Reproductive and Urinary Physiology | Urology
Ureters; Ureters Obstructions.
Primary Language of Manuscript