Influence of β1 -adrenoceptor polymorphisms on the expression of β1 -adrenoceptors in human lung tissue
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Human lung tissue contains both β2 - and β1 -adrenoceptors at a reported ratio of 4:1 (Sano et al., 1993). However, previous work within our group has shown extensive variability in the expression of β-adrenoceptors in human lung. The possibility that genetic polymorphisms in β-adrenoceptor genes might influence receptor expression has been explored. A statistically significant (P<0.05) association between a single nucleotide polymorphism (SNP) in the β2-adrenoceptor gene (491 C>T) and β2-adrenoceptor expression has been observed in human lung tissue (data unpublished). The aim of the present study was to determine whether a similar association might exist between two common SNPs (145 A>G (Ser49Gly) and 1165 C>G (Arg389Gly)) in the β1-adrenoceptor gene and β1-adrenoceptor expression. © 2007 pA2 Online
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