Does the addition of RDW improve current ICU scoring systems?

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Loveday, S., Sinclair, L., & Badrick, T. (2015). Does the addition of RDW improve current ICU scoring systems? Clinical biochemistry. 48(9), 569-574.

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© Copyright, The Canadian Society of Clinical Chemists, 2015

2015 HERDC Submission




Background: The aimof this study was to evaluate whether the addition of red blood cell distribution width (RDW) improves the prognostic value of current intensive care unit (ICU) scoring systems, namely APACHE III. Design andMethods: All patients admitted to a mixed ICU in Brisbane between June 2013 and July 2014 for whom RDWwas available were included in the study. Analyses included descriptive statistics, linear regression correlation, and receiver operating characteristic (ROC) curves. Results: The study included 708 patients for whomboth ICUmortality prediction and RDWwere available. In univariate analysis higher RDW values were associated with increased hospital mortality. Adding RDW to APACHE III increased the area under the ROC marginally (from 0.9586 to 0.9613). RDW was not correlated with C-reactive protein, white cell count, or patient's length of stay in ICU. Conclusion: RDWwas an independent predictor of mortality. The addition of RDWto APACHE III improved itsmortality prediction marginally. The underlying mechanismof RDWelevation warrants further investigation.

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