Project Title

The genetics of exercise-induced injuries involving tendon and bone


This is a genome-wide association study (GWAS) aimed at identifying genetic polymorphisms associated with the incidence of Achilles tendinopathy and bone stress injuries in the lower extremities. Due to the high popularity of running in Australia and relative high incidence of overuse injuries during running, recreational runners were selected as the study group. An online questionnaire approach was selected as a method of collecting epidemiological data on Australian runners and to provide a platform for the selection of the appropriate candidates to the GWAS study.

Research question:

1. What are the genetic contributors to the development of overuse injuries and what biological and physiological processes they influence? Recreational runners were selected as a focus group for recruitment. A questionnaire was delivered using a commercial online survey software package (SurveyGizmo). The questionnaire was designed to collect epidemiological data of recreational runners and enable to select participants for the genetic part of the project. Test-retest reliability study showed that the survey is reliable and meets the recruitment needs for the project (1). The two main criteria for participation in the survey were that the participants were over the age of 18 and ran a distance of at least 15 km per week. BC Platform software will be used for GWAS data storage and analysis and R software will also be used for data analysis.


GWAS, Genome wide association study, Achilles tendinopathy, Bone stress, Australia

Document Type

Research Methodology

Lead Organisation

Australian Institute of Sport

Publication Year


Distribution License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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