We would like to look across the lifespan at healthy people with risk factors for chronic disease, people with early stage chronic disease and people with longstanding chronic disease. We have three basic study designs we would propose, within which we will address the hypotheses linking genetic profile and phenotypic adaptation to exercise, as noted below:

  1. Conduct cross-sectional analyses across the lifespan to specify the genetic profiles that explain a portion of the variance in the following five domains relevant to chronic disease:
    • Body Composition & Nutritional status
    • Exercise Capacity and Performance
    • Cardiovascular and Metabolic Risk Profile
    • Neurological & Psychological Function
    • Musculoskeletal Morphology and Metabolism
  2. Determine genetic profiles that predict the severity or presentation of specific chronic diseases which have been linked to lifestyle (particularly cardiometabolic and musculoskeletal disease), as well as genetic profiles that predict robust changes and adaptations related to lifestyle interventions across the above five themes.
  3. Measure change in epigenetic profile, mRNA and protein expression to assess if epigenetic regulation of gene expression changes over time due to lifestyle interventions and whether these changes predict a portion of the adaptation to lifestyle modification.

Project team

This study will be led by Professor Maria Fiatarone Singh at University of Sydney, with input from all partners in the CRN.