In this thesis mechanisms underlying bladder mechanosensation were investigated both directly, using an in vitro afferent nerve recording technique which allowed the concurrent recording of intravesical pressure and afferent nerve activity, and indirectly, examining urothelial mediator release and intracellular calcium signalling of urothelial cells and isolated DRG neurons. Using a combination of mechanical, pharmacological and genetic tools, a role for P2X, P2Y, TRPV1 and NK2 receptors in influencing mechanosensitivity was investigated.
Year Manuscript Completed
Urinary organs; Bladder.
Primary Language of Manuscript
Recommended CitationLuke Alexander Grundy (2014) Non-Neuronal ATP : Regulation of Release and Action in the Bladder, PhD, ePublications@bond, Faculty of Health Sciences and Medicine.
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