The aim of this PhD project was to increase our understanding of the pharmacology of the urethra and the anorectum. Specifically, the intent was to elucidate the pharmacology of the smooth muscle of the urethra and the anorectum; to establish the influence of the urothelial lining on urethral contraction; to investigate the mediators and neurotransmitters involved in the regulation of these tissues and to characterise the intracellular signalling pathways involved in contraction and relaxation.

Year Manuscript Completed



Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Reproductive and Urinary Physiology | Urology


Urinary stress incontinence; Anal fistula; Urinary incontinence, Stress; Fissure in Ano.

Primary Language of Manuscript