Date of this Version

12-1-2010

Document Type

Journal Article

Publication Details

Published Version.

Sharpley, C.F. & Bitsika, V. (2010). Joining the dots: Neurobiological links in a functional analysis of depression. Behavioral and brain functions, 6:73.

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2010 HERDC submission. FoR Code: 170100

© Copyright Sharpley and Bitsika, 2010; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Depression is one of the major contributors to the Total Disease Burden and afflicts about one-sixth of Western populations. One of the most effective treatments for depression focuses upon analysis of causal chains in overt behaviour, but does not include brain-related phenomena as steps along these causal pathways. Recent research findings regarding the neurobiological concomitants of depressive behaviour suggest a sequence of structural and functional alterations to the brain which may also produce a beneficial outcome for the depressed individual--that of adaptive withdrawal from uncontrollable aversive stressors. Linking these brain-based explanations to models of observable contingencies for depressive behaviour can provide a comprehensive explanation of how depressive behaviour occurs and why it persists in many patients.

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This document has been peer reviewed.

 

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