Title

Cardiovascular adenosine receptors: Expression, actions and interactions

Date of this Version

1-1-2013

Document Type

Journal Article

Publication Details

Citation only

Headrick, J. P., Ashton, K. J., Rose'Meyer, R. B., & Peart, J. N. (2013). Cardiovascular adenosine receptors: Expression, actions and interactions. Pharmacology and Therapeutics, 140(1), 92-111.

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© Copyright, Elsevier, 2013

2013 HERDC submission. FoR code: 060405;060603;110201

ISSN

0163-7258

Abstract

Intra- and extracellular adenosine levels rise in response to physiological stimuli and with metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular adenosine engages members of the G-protein coupled adenosine receptor (AR) family to mediate generally beneficial acute and adaptive responses within all constituent cells of the heart. In this way the four AR sub-types - A1, A2A, A2B, and A 3Rs - regulate myocardial contraction, heart rate and conduction, adrenergic control, coronary vascular tone, cardiac and vascular growth, inflammatory-vascular cell interactions, and cellular stress-resistance, injury and death. The AR sub-types exert both distinct and overlapping effects, and may interact in mediating these cardiovascular responses. The roles of the ARs in beneficial modulation of cardiac and vascular function, growth and stress-resistance render them attractive therapeutic targets. However, interactions between ARs and with other receptors, and their ubiquitous distribution throughout the body, can pose a challenge to the implementation of site- and target-specific AR based pharmacotherapy. This review outlines cardiovascular control by adenosine and the AR family in health and disease, including interactions between AR sub-types within the heart and vessels.

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This document has been peer reviewed.