Title

The ongoing battle against multi-resistant strains: In-vitro inhibition of hospital-acquired MRSA, VRE, pseudomonas, ESBL E. coli and klebsiella species in the presence of plant-derived antiseptic oils

Date of this Version

1-1-2013

Document Type

Journal Article

Publication Details

Citation only

Warnke, P. H., Lott, A. J. S., Sherry, E., Wiltfang, J., & Podschun, R. (2013). The ongoing battle against multi-resistant strains: In-vitro inhibition of hospital-acquired MRSA, VRE, pseudomonas, ESBL E. coli and klebsiella species in the presence of plant-derived antiseptic oils. Journal of Cranio-Maxillofacial Surgery, 41(4), 321-326.

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© Copyright, European Association for Cranio-Maxillo-Facial Surgery, 2013

2013 HERDC Submission. FoR code: 100404;110504

ISSN

1010-5182

Abstract

The fight against hospital-acquired infections involving antibiotic-resistant microorganisms has become of critical concern to surgeons worldwide. In addition to the development of new effective antibiotic chemotherapy, exploration of 'forgotten' topical antibacterial agents from the pre-antibiotic era has recently gained new attention. We report the promising efficacy of plant-derived antiseptic oils used in traditional aboriginal and south-east Asian treatments such as Lemongrass, Eucalyptus and Tea Tree Oil in the inhibition of clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), multi-resistant Pseudomonas aeruginosa, ESBL-producing Escherichia coli and Klebsiella pneumoniae in the in-vitro setting. Large consistent zones of inhibition were observed for all three plant-derived oils tested in an agar diffusion test. The commonly used antibacterial agents chlorhexidine 0.1%, and ethanol (70%), and standard olive oil consistently demonstrated notably lower or no efficacy in regard to growth inhibition of strains. Notably, Lemongrass oil proved to be particularly active against gram-positive bacteria, while Tea Tree oil showed superior inhibition of gram-negative microorganisms. As proven in vitro, plant-derived antiseptic oils may represent a promising and affordable topical agent to support surgical treatment against multi-resistant and hospital-acquired infections. © 2012 European Association for Cranio-Maxillo-Facial Surgery.

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This document has been peer reviewed.