Date of this Version

1-1-2012

Document Type

Journal Article

Publication Details

Citation only

Djulbegovic, B., Kumar, A., Glasziou, P. P., Perera, R., Reljic, T., Dent, L., Raftery, J., Johansen, M., Di Tanna, G.L, Miladinovic, B., Soares, H., Visit, G. & Chalmers, I. (2012). New treatments compared to established treatments in randomized trials. Cochrane Database of Systematic Reviews (Online), 10.

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© Copyright, The Cochrane Collaboration, 2012

NHMRC Project Grant GNT0527500

ISSN

1469-493X

Abstract

BACKGROUND: The proportion of proposed new treatments that are 'successful' is of ethical, scientific, and public importance. We investigated how often new, experimental treatments evaluated in randomized controlled trials (RCTs) are superior to established treatments. OBJECTIVES: Our main question was: "On average how often are new treatments more effective, equally effective or less effective than established treatments?" Additionally, we wanted to explain the observed results, i.e. whether the observed distribution of outcomes is consistent with the 'uncertainty requirement' for enrollment in RCTs. We also investigated the effect of choice of comparator (active versus no treatment/placebo) on the observed results.

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