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We employed transcranial magnetic stimulation (TMS) over the primary somatosensory cortex (SI) in human subjects to investigate the extent to which inactivating SI disrupted the discrimination of vibrotactile stimulation at frequencies that give rise to the tactile sensations of flutter (30Hz) and vibration (200Hz). Discrimination at the 30Hz standard following application of TMS to SI was reduced in seven of the eight subjects, and at the 200Hz standard was reduced in all eight subjects. The average change in discrimination following TMS was about 20% for both low and high frequencies of vibrotactile stimulation. The results of this study provide functional evidence in favour of a serial model of information processing in primary and secondary somatosensory cortical regions in humans.