Title

Nanospiderwebs: Artificial 3D extracellular matrix from nanofibers by novel clinical grade electrospinning for stem cell delivery

Date of this Version

5-1-2013

Document Type

Journal Article

Publication Details

Citation only

Alamein, M., Liu, Q., Stephens, S., Skabo, S., Warnke, F., Bourke, R., Heiner, P., & Warmke, P. (2013). Nanospiderwebs: Artificial 3D extracellular matrix from nanofibers by novel clinical grade electrospinning for stem cell delivery. Advanced Healthcare Materials, 2(5), 702-717

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Copyright © 2013 European Association for Cranio-Maxillofacial Surgery

2013 HERDC submission. FoR code: 100404;110504

ISSN

2192-2659

Abstract

Novel clinical grade electrospinning methods could provide three-dimensional (3D) nanostructured biomaterials comprising of synthetic or natural biopolymer nanofibers. Such advanced materials could potentially mimic the natural extracellular matrix (ECM) accurately and may provide superior niche-like spaces on the subcellular scale for optimal stem-cell attachment and individual cell homing in regenerative therapies. The goal of this study was to design several novel “nanofibrous extracellular matrices” (NF-ECMs) with a natural mesh-like 3D architecture through a unique needle-free multi-jet electrospinning method in highly controlled manner to comply with good manufacturing practices (GMP) for the production of advanced healthcare materials for regenerative medicine, and to test cellular behavior of human mesenchymal stem cells (HMSCs) on these

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This document has been peer reviewed.