Title

Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure

Date of this Version

6-1-2012

Document Type

Journal Article

Publication Details

Citation only

Smart, N.A., Meyer, T., Butterfield, J.A., Faddy, S.C., Passino, C., Malfatto, G., Jonsdottir, S., Sarullo, F., Wisloff, U., Vigorito, C., & Giallauria, F. (2012). Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure. European Journal of Preventive Cardiology, 19(3), 428-435

Access the journal

2012 HERDC submission. FoR codes: 110604; 110201; 110312

© Copyright The European Society of Cardiology, 2011

ISSN

2047-4881

Abstract

Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP.

Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO2; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO2.

Design: Individual patient meta-analysis.

Methods: A systematic search was conducted of Medline (Ovid), Embase.com, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO2. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures.

Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (−28.3%, p

Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO2 in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO2 changes.

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This document has been peer reviewed.