Title

Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children (Review)

Date of this Version

1-18-2012

Document Type

Journal Article

Publication Details

Published version

Jefferson, T., Jones, M.A., Doshi, P., Del Mar, C.B., Heneghan, C.J., Hama, R., Thompson, M.J. (2012). Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children (Review). Cochrane Database of Systematic Reviews, 2013(6). Art. No.: CD008965T

Access the journal

2012 HERDC submission. FoR codes:111717; 110399

© Copyright The Cochrane Collaboration, 2013

See 2014 update of this review

ISSN

1469-493X

Abstract

Background: Planning for outbreaks of influenza is a high priority public health issue for national governments. Neuraminidase inhibitors (NIs) are thought to help reduce the symptoms of influenza with several possible mechanisms proposed. NIs have been stockpiled with a view to their widespread use in the event of a pandemic. However, the evidence base for this class of agents remains a source of debate. In a previous review we have documented substantial risks of publication bias of trials of NIs for influenza (60% of patient data from phase III treatment trials of oseltamivir have never been published) and reporting bias in the published trials. Our confidence in the conclusions of previous versions of this review has been subsequently undermined. Since we have become aware of a large number of unpublished trials of NIs in the management of influenza, this review updates and merges existing reviews in this area.

 

This document has been peer reviewed.