Title

Modifiable lifestyle and environmental risk factors affecting the retinal microcirculation

Date of this Version

12-21-2012

Document Type

Journal Article

Publication Details

Citation only

Serre, K., & Sasongko, M. (2012). Modifiable lifestyle and environmental risk factors affecting the retinal microcirculation. Microcirculation, 19(1), 29–36

Access the journal

2012 HERDC submission. FoR codes: 110300

© Copyright John Wiley & Sons Ltd

ISSN

0022-5347

Abstract

Structural changes within the human retinal vasculature may reflect systemic vascular changes associated with various cardiovascular and metabolic disorders. Recent data suggest that systemic exposure from a range of modifiable lifestyle and environmental risk factors (e.g., diet, physical activity, and smoking) may affect the morphology of the retinal vasculature. Being easily accessible and non-invasively visualized, the retinal microvasculature therefore can be a clinically useful biomarker of reversible sub-clinical physiologic deviation of the systemic circulation as results of such unfavorable exposures. Importantly, quantitative analysis of the retinal microvasculature may be utilized as a prognostic tool, allowing for targeted vascular therapies before the onset of overt cardiovascular and metabolic disorders. This review summarizes the modifiable lifestyle and environmental risk factors that affect retinal microvascular structure and the possible clinical implications of such relationships.

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This document has been peer reviewed.