Title

Influence of β1 -adrenoceptor polymorphisms on the expression of β1 -adrenoceptors in human lung tissue

Date of this Version

December 2006

Document Type

Journal Article

Publication Details

Kay, L.J., Suvarna, S.K., Chess-Williams, Russ and Peachell, Peter T. (2006) Influence of β1 -adrenoceptor polymorphisms on the expression of β1 -adrenoceptors in human lung tissue is published in pA2 Online, Volume 4, Issue 2, December 2006.
To view the published article contact pA2 Online

2006 HERDC submission

Abstract

Human lung tissue contains both β2 - and β1 -adrenoceptors at a reported ratio of 4:1 (Sano et al., 1993). However, previous work within our group has shown extensive variability in the expression of β-adrenoceptors in human lung. The possibility that genetic polymorphisms in β-adrenoceptor genes might influence receptor expression has been explored. A statistically significant (P<0.05) association between a single nucleotide polymorphism (SNP) in the β2-adrenoceptor gene (491 C>T) and β2-adrenoceptor expression has been observed in human lung tissue (data unpublished). The aim of the present study was to determine whether a similar association might exist between two common SNPs (145 A>G (Ser49Gly) and 1165 C>G (Arg389Gly)) in the β1-adrenoceptor gene and β1-adrenoceptor expression. © 2007 pA2 Online

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This document has been peer reviewed.