The Effect of Resting Tension, pH and Temperature on Urothelium-Derived Inhibitory Factor Attenuation of Detrustor Contractility
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The presence of urothelium inhibits maximal bladder contractions by approximately 50% in response to carbachol in pig and human isolated muscle strips [1, 2]. This inhibitory effect has been attributed to release of diffusible urothelium derived inhibitory factor (UDIF). The UDIF is yet to be identified but there is evidence to suggest that it is neither nitric oxide nor cycloxygenase product. Discovering more about the UDIF may lead to the discovery of novel targets for the clinical treatment of detrusor overactivity. The aim of this study was to identify whether the UDIF's mechanism of action or release, are altered when the general conditions of the in vitro experiment are changed. The effect of altering the pH, temperature and the resting tension on detrusor contractility and urothelial inhibition were observed. The results of this study may provide fundamental clues to UDIF's identity.
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