Title

The α1A/L-Adrenoceptor Subtype Mediates Contraction of the Internal Anal Sphincter to Noradrenaline

Date of this Version

12-1-2006

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Chess-Williams, Russ, Shorthouse, A. and Hausman, N. (2006) The α1A/L-Adrenoceptor Subtype Mediates Contraction of the Internal Anal Sphincter to Noradrenaline is published in Neurourology and Urodynamics, Volume 25, Issue 6, December 2006.
To view the published article contact Neurourology and Urodynamics

2006 HERDC submission

Abstract

Contraction of the internal anal sphincter contributes 50-85% towards resting anal tone. Small clinical trials with phenylephrine suggest that α1-adrenoceptor agonists could be used to increase IAS tone as a treatment for faecal incontinence. However, there are three subtypes of α1-adrenoceptor, namely α1A, α1B and α1D. It is possible that the α1A-subtype may also exist in another form known as the α1L-adrenoceptor which has a low affinity for prazosin. The aim of the present study was to determine the α1-adrenoceptor subtypes present in the IAS, with a view to possibly finding a more specific therapeutic target for the treatment of faecal incontinence.

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This document has been peer reviewed.