The Effect of â-Adrenoceptor Agonists on Detrusor Contraction in the Presence and Absence of Urothelium
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It is known that stimulating muscarinic receptors in bladder urothelium causes the release of nitric oxide and an unidentified diffusible factor that inhibits contractions of the detrusor muscle. The relaxation of the detrusor muscle via B-adrenoceptors is thought to contribute to urine storage during bladder filling. That is why B-adrenoceptor agonists are thought to be a potential treatment for detrusor overactivity. However, there is little information about the relationship between urothelium and B-adrenoceptors. Therefore we investigated whether the responses of pig bladder induced by B-adrenoceptor agonists are affected by the urothelium. Furthermore, we also studied whether adrenergic-evoked nitric oxide, which is reported to be released from urothelium, was affected by B-adrenoceptor agonists.
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