Title

Red blood cell aggregation parameters measured by capillary tube aggregometer using venous and capillary blood samples

Date of this Version

12-1-2011

Document Type

Journal Article

Publication Details

Citation only

Simmonds, M. J., Christy, R. M., Marshall-Gradisnik, S. M., Meiselman, H. J., et al. (2011). Red blood cell aggregation parameters measured by capillary tube aggregometer using venous and capillary blood samples. Korea - Australia Rheology Journal, 23 (4), 205-210.

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2011 HERDC submission. FoR code: 111701, 119999

© Copyright The Korean Society of Rheology and Springer, 2011

ISSN

2093-7660

Abstract

The extent of red blood cell (RBC) aggregation has widely been accepted as a reliable indicator of inflammatory processes. The ability to measure RBC aggregation indexes in capillary blood samples may simplify the application of the test and may bring advantages in its clinical usage as well as application in field studies. This study compared RBC aggregation indexes measured in venous and capillary blood samples using a newly developed capillary tube aggregometer. Although strong correlations between agreegation indexes measured in capillary and venous samples were detected, the indexes measure in venous samples were higher compared to capillary samples, thus indicating a bias. The possible reason for this bias is proposed to be related to the difference in oxygen saturation of venous and capillary samples and therefore altered the light absorption spectrums. Our results indicate that capillary blood samples can be used to estimate RBC aggregation in venous blood samples, however the bias should be taken into account.

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This document has been peer reviewed.