Title

Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat

Date of this Version

July 2006

Document Type

Journal Article

Publication Details

Naiker, Dineshree V., Catts, Stanley V., Catts, Vibeke S., Bedi, Kuldip S. and Bryan-Lluka, Lesley J. (2006) Dose determination of haloperidol, risperidone and olanzapine using an in vivo dopamine D2-receptor occupancy method in the rat is published in European Journal of Pharmacology, Volume 540, Issue 1-3, July 2006, pp. 87-90.
To obtain a copy of the published article contact the European Journal of Pharmacology

2006 HERDC submission

Abstract

The purpose of the present study was to determine antipsychotic doses that achieve 80% striatal dopamine D2-receptor occupancy for haloperidol, risperidone and olanzapine in rats. Wistar rats were treated with normal saline vehicle (controls), haloperidol (0.25 and 0.5 mg/kg/day), risperidone (3, 5 and 6 mg/kg/day) and olanzapine (5 and 10 mg/kg/day) for 7 days via osmotic minipumps. Striatal and cerebellar tissue were collected and in vivo dopamine D2-receptor occupancies were determined using 3H-raclopride. The doses required to achieve dopamine D2-receptor occupancy of 80% in 11- and 24-week old rats were: haloperidol 0.25 mg/kg/day, risperidone 5 mg/kg/day and olanzapine 10 mg/kg/day. Copyright © 2007 Elsevier

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