Title

Cardiovascular dynamics during exercise are related to blood rheology

Date of this Version

1-1-2011

Document Type

Journal Article

Publication Details

Citation only

Simmonds, M. J., Tripette, J., Sabapathy, S., Marshall-Gradisnik, S. M., et al. (2011). Cardiovascular dynamics during exercise are related to blood rheology. Clinical Hemorheology and Microcirculation, 49 (1-4), 231-241.

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2011 HERDC submission. FoR code: 110300

© Copyright IOS Press and the authors, 2011. All rights reserved.

ISSN

1386-0291

Abstract

Background:
The principal determinants of oxygen uptake (VO2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in VO2 and cardiac output (Qc), or steady-state arteriovenous oxygen difference (a-vO2D) during submaximal cycling.

Methods and Results:

Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; bodymass index: 22.7 ± 2.0 kg..m-2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state VO2 during exercise and the a-vO2D at rest (r= -0.73, p < 0.05), and positively correlated to Qc at rest (r = 0.71, p < 0,05). Blood viscosity at various shear rates was negatively correlated with the time constant of VO2 (all p
Conclusions:
The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.

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This document has been peer reviewed.