Title

Is there a potential immune dysfunction with anabolic androgenic steroid use?: A review

Date of this Version

5-1-2011

Document Type

Journal Article

Publication Details

Citation only

Brenu, E W, McNaughton, L R & Marshall-Gradisnik, S M (2011). Is there a potential immune dysfunction with anabolic androgenic steroid use? A review. Mini - Reviews in Medicinal Chemistry, 11 (5), 438-445.

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2011 HERDC submission. FoR code: 030400, 111500

© Copyright Bentham Science Publishers Ltd., 2011

ISSN

1389-5575

Abstract

Anabolic androgenic steroids (AAS) are artificial substances, acting through androgen receptors and were primarily developed for the treatment of hypogonadism, tumors, hypercalcemia, hypercalcuria and other chronic diseases. The discovery, in the early 1930s that these substances may have other benefits related to improvement in physique and athletic performance, has encouraged extensive use of these substances by amateur and professional athletes and members of the general public. The range of AAS used can be classified as either endogenous or exogenous. When used for ergogenic or recreational purposes the dosage is more often higher than the recommended dosage, and at supraphysiological levels, AAS can cause a number of serious side effects including liver dysfunction, myocardial infarction and potentially stroke, due to its ability to increase platelet and platelet aggregation. Furthermore, these high dosages may or can affect other physiological systems including the immune system. Hence, this paper reviews the current research on the effects of a number of specific AAS in the immune system.

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This document has been peer reviewed.