Title

Fatal bilateral pneumothoraces following administration of aerosolised pentamidine

Date of this Version

10-1-2011

Document Type

Journal Article

Publication Details

Citation only

Green, A., Milne, N., & Ong, B. (2011). Fatal bilateral pneumothoraces following administration of aerosolised pentamidine. Journal of Clinical Forensic and Legal Medicine: An international journal of forensic and legal medicine, 18 (7) ,332-335.

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2011 HERDC submission. FoR code: 110300

© Copyright Elsevier Ltd and Faculty of Forensic and Legal Medicine, 2011. All rights reserved.

ISSN

1752-928X

Abstract

Aerosolised pentamidine (AP) is used for prophylaxis against infection with Pneumocystis jiroveci (carinii), a significant cause of morbidity and mortality for people with human immunodeficiency virus (HIV). In this article we report a 55 year old man with HIV and a background history of asthma since childhood, who suffered respiratory arrest and died within an hour of commencing AP prophylaxis. Autopsy revealed bilateral pneumothoraces. Common side effects of AP therapy include bronchospasm and coughing. Pneumothorax has been reported in several cases. To our knowledge, this is the first reported fatality from bilateral pneumothoraces.

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This document has been peer reviewed.