Title

GRADE guidelines: 9. Rating up the quality of evidence

Date of this Version

12-1-2011

Document Type

Journal Article

Publication Details

Citation only

Guyatt, G. H., Oxman, A. D., Sultan, S., Glasziou, P. P., et al. (2011). GRADE guidelines: 9. Rating up the quality of evidence. Journal of clinical epidemiology, 64 (12), 1311-1316.

Access the journal's website.

2011 HERDC submission. FoR code: 111700

© Copyright Elsevier Inc., 2011. All rights reserved.

ISSN

0895-4356

Abstract

The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect. Other considerations include the rapidity of the response, the underlying trajectory of the condition, and indirect evidence.

This document is currently not available here.

Share

COinS
 

This document has been peer reviewed.