Title

Embolisation therapy for pulmonary arteriovenous malformations (Review)

Date of this Version

1-1-2010

Document Type

Journal Article

Publication Details

Citation only.

Hsu, C. C. T., Kwan, G. N. C., Thompson, S. A., & van Driel, M. L. (2010). Embolisation therapy for pulmonary arteriovenous malformations (Review). Cochrane Database of Systematic Reviews, 5, 1-14.

Access the Journal's homepage.

2010 HERDC submission. FoR Code: 110399, 111717, 111706

© Copyright 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Abstract

Background: Pulmonary arteriovenous malformations are abnormal direct connections between the pulmonary artery and pulmonary vein which result in a right-to-left shunt. They are associated with substantial morbidity and mortality mainly from the effects of paradoxical emboli. Potential complications include stroke, cerebral abscess, pulmonary haemorrhage and hypoxaemia. Embolisation therapy is a form of treatment based on the occlusion of the feeding arteries to a pulmonary arteriovenous malformation and can prevent many of these debilitating and life-threatening complications.

Objectives: To determine the efficacy and safety of embolisation therapy in people with pulmonary arteriovenous malformations including a comparison with surgical resection and different embolisation devices.

Search Strategy: We searched the Cystic Fibrosis and Genetic Disorders Group's Trials Registers (last searched 07 September 2009). We also searched the following databases: the Australian New Zealand Clinical Trials Registry; ClinicalTrials.gov; International Standard Randomised Controlled Trial Number Register; International Clinical Trials Registry Platform Search Portal (last searched 22 November 2009). We checked cross-references and searched references from review articles. Finally, we contacted manufacturers and specialised centres for unpublished and ongoing trials.

Selection Criteria: Trials in which individuals with pulmonary arteriovenous malformations were randomly allocated to embolisation therapy compared to no treatment, surgical resection or a different embolisation device. Studies identified for potential inclusion were independently assessed for eligibility by two authors, with excluded studies further checked by a third author.

Data Collection and Analysis: No trials were identified. As this was the case, no analysis was performed.

Main Results: There were no randomised controlled trials identified.

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This document has been peer reviewed.