Title

Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus

Date of this Version

4-1-2010

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Ueno, T., Miki, T., Wang, Z-Y., Yokoyama, T., Lee, K-Y., Kusaka, T., Warita, K., Sumitani, K., Matsumoto, Y., Yakura, T., Liu, J-Q., Bedi, K. S., & Takeuchi, Y. (2010). Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus. Current Neurobiology, 1(1), 40-45.

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2010 HERDC submission. FoR Code: 110999

© Copyright 2010 Scientific Publishers of India. All rights reserved.

Abstract

Alcohol ingestion has adverse effects on the central nervous system (CNS). The hippocampus is one of the target sites of ethanol neurotoxicity. We hypothesized that short-term ethanol exposure alters the expression of neurotrophins and their receptors, leading to functional disruption in the CNS. Male BALB/C mice were fed a liquid diet containing 5% (v/v) ethanol. Pair-fed control mice were maintained on an identical liquid diet, except that ethanol was isocalorically substituted with sucrose. The hippocampus of mice exhibiting stages 1-2 of ethanol intoxication signs were used in the present study. Short-term ethanol exposure did not alter the mRNA expression of neurotrophin ligand/receptor (nerve growth factor [NGF]/TrkA and brain-derived neurotrophic factor [BDNF]/TrkB) systems in the hippocampus. Similarly, the expression of the glial-derived neurotrophic factor (GDNF), which is known to be a first-acting agent against ethanol neurotoxicity, and its receptor GFR?1 was not affected by short-term ethanol exposure. The mechanisms involved in the hippocampal neurotrophin responses against ethanol neurotoxicity remain unknown. However, our findings could provide a basis for further studies on the possible alterations in the expression of various neurotrophins related to hippocampal functions.

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This document has been peer reviewed.