Title

Ulcerated malignant spindle-cell neoplasm of the finger: Malignant peripheral nerve sheath tumor or desmoplastic malignant melanoma?

Date of this Version

2009

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Connelly, T., Mones, J., & Dixon, A. (2009). Ulcerated malignant spindle-cell neoplasm of the finger: Malignant peripheral nerve sheath tumor or desmoplastic malignant melanoma? Dermatologic surgery, 35(12), 2013-2018.

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2009 HERDC submission. FoR Code: 1103

© Copyright the American Society for Dermatologic Surgery, Inc., 2009

Abstract

Extract:

Malignant peripheral nerve sheath tumors (MPNSTs) usually occur in the deep soft tissues in patients with neurofibromatosis type 1 (NF-1) in association with or arising from a peripheral nerve, but MPNSTs may also occur in patients without evidence of NF-1. MPNSTs used to be referred to as neurofibrosarcomas, neurogenic sarcomas, malignant schwannomas, and ‘‘Triton tumors’’ when heterologous mesenchymal elements such as rhabdomyosarcoma, leiomyosarcoma, chondrosarcoma, or osteosarcoma were present, but MPNST is now the preferred term. MPNSTs may also arise in the skin, and these neoplasms are referred to as cutaneous or superficial MPNSTs (SMPNSTs). MPNSTs, as a group, are rare, and SMPNSTs are even rarer.

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This document has been peer reviewed.