Title

Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice

Date of this Version

2009

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Uchiyama, J., Maeda, Y., Takemura, I., Chess-Williams, R., Wakiguchi, H., & Matsuzaki, S. (2009). Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice. Microbiology and immunology, 53(5), 301-304.

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2009 HERDC submission. FoR code: 0605; 1107; 1108

© Copyright 2009 The Societies and Blackwell Publishing Asia Pty Ltd

Abstract

Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.

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This document has been peer reviewed.