Title

The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans

Date of this Version

2009

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Voisey, J., Swagell, C. D., Hughes, I. P., Morris, C. P., van Daal, A., Noble, E. P., Kann, B., Heslop, K. A., Young, R. M., & Lawford, B. R. (2009). The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans. Depression and anxiety, 26(1), 28-33.

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2009 HERDC submission. FoR code: 1103; 1701

© Copyright 2008 Wiley-Liss, Inc.

Abstract

Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C>T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain.

Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD.

Results: No significant association was found between PTSD and the Taq1A or -141delC polymorphisms. However, a significant association was observed with PTSD and the 957C>T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P=0.021).

Conclusions: Our findings suggest that the 957C>T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.

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This document has been peer reviewed.