Date of this Version

9-27-2016

Document Type

Journal Article

Publication Details

Accepted version

Smiles, W. J., Parr, E. B., Coffey, V. G., Lacham-Kaplan, O., Hawley, J. A., & Camera, D. M. (2016, in press). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. AJP: Endocrinology and Metabolism, 311(5), E836-E849.

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Copyright © 2016, American Journal of Physiology-Endocrinology and Metabolism

ISSN

1522-1555

Abstract

Alcohol ingestion decreases post-exercise rates of muscle protein synthesis, but the mechanism(s) (e.g., increased protein breakdown) underlying this observation are unknown. Autophagy is an intracellular "recycling" system required for homeostatic substrate and organelle turnover; its dysregulation may provoke apoptosis and lead to muscle atrophy. We investigated the acute effects of alcohol ingestion on autophagic cell signaling responses to a bout of concurrent (combined resistance- and endurance-based) exercise. In a randomized cross-over design, 8 physically active males completed three experimental trials of concurrent exercise with either post-exercise ingestion of alcohol and carbohydrate (12±2 standard drinks; ALC-CHO), energy-matched alcohol and protein (ALC-PRO), or protein (PRO) only. Muscle biopsies were taken at rest and 2 and 8 h post-exercise. Select autophagy-related gene (Atg) proteins decreased compared to rest with ALC-CHO (P

Available for download on Wednesday, November 01, 2017

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This document has been peer reviewed.