Date of this Version

7-5-2016

Document Type

Journal Article

Publication Details

Published version

Hall, S., Rudrawar, S., Zunk, M., Bernaitis, N., Arora, D., McDermott, C. M., & Anoopkumar-Dukie, S. (2016). Protection against radiotherapy-induced toxicity. Antioxidants, 5(3), 22.

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Copyright © 2016 The Authors; licensee MDPI, Basel, Switzerland.

Distribution License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN

2076-3921

Abstract

Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

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