Date of this Version

4-21-2016

Document Type

Journal Article

Publication Details

Published version

Parr, E. B., Camera, D. M., Burke, L. M., Phillips, S. M., Coffey, V. G., & Hawley, J. A. (2016). Circulating microrna responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE, 11(4),1-14.

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© Copyright, 2016 Parr et al.

Distribution License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN

1932-6203

Abstract

Background:

Interactions between diet, physical activity and genetic predisposition contribute to variable body mass changes observed in response to weight loss interventions. Circulating micro-RNAs (c-miRNAs) may act as 'biomarkers' that are associated with the rate of change in weight loss, and/or play a role in regulating the biological variation, in response to energy restriction.

Objective:

To quantify targeted c-miRNAs with putative roles in energy metabolism and exercise adaptations following a 16 wk diet and exercise intervention in individuals with large (high responders; HiRes) versus small (low responders; LoRes) losses in body mass.

Methods:

From 89 male and female overweight/obese participants who completed the intervention (energy restriction from diet, 250 kcal/d, and exercise, 250 kcal/d), subgroups of HiRes (>10% body mass loss, n = 22) and LoRes (

Results:

Loss of body mass (-11.0 ± 2.3 kg vs. -3.0 ± 1.3 kg; P

Conclusion

The differential expression and responses of selected c-miRNAs in overweight/obese individuals to an exercise and diet intervention suggests a putative role for these 'biomarkers' in the prediction or detection of individual variability to weight loss interventions

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