Title

Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible

Date of this Version

6-1-2006

Document Type

Journal Article

Publication Details

Interim status: Citation only.

Warnke, P. H., Wiltfang, J., Springer, I., Acil, Y., Bolte, H., Kosmahl, M., Russo, P. A., Sherry, E., Lützen, U., Wolfart, S. & Terheyden, H. (2006). Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible. Biomaterials, 27(17), 3163-3167.

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© Copyright Elsevier Ltd, 2006

Abstract

In 2004, we reported a novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials.

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This document has been peer reviewed.