Title

Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: Protocol for DIET-HD, a prospective multinational cohort study

Authors

Suetonia C. Palmer, Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand
Marinella Ruospo, Diaverum Medical Scientific Office, Lund, Sweden
Katrina Campbell, Bond UniversityFollow
Vanessa G. Larsen, Imperial College of Science, Technology, and Medicine, London, UK
Valeria Saglimbene, Diaverum Medical Scientific Office, Lund, Sweden
Patrizia Natale, Diaverum Medical Scientific Office, Lund, Sweden
Letizia Gargano, Diaverum Medical Scientific Office, Lund, Sweden
Jonathan C. Craig, University of SydneyFollow
David W. Johnson, Princess Alexandra HospitalFollow
Marcello Tonelli, University of Calgary, Canada
John Knight, The George Institute for Global Health, Sydney
Anna Bednarek-Skublewska, Medical University of Lublin, Lublin, Poland
Eduardo Celia, Diaverum Medical Scientific Office, Lund, Sweden
Domingo del Castillo, Diaverum Medical Scientific Office, Lund, Sweden
Jan Dulawa, Medical University of Silesia, Katowice, Poland
Tevfik Ecder, Diaverum Medical Scientific Office, Lund, Sweden
Elisabeth Fabricius, Diaverum Medical Scientific Office, Lund, Sweden
Joao M. Frazao, Diaverum Medical Scientific Office, Lund, Sweden
Ruben Gelfman, Diaverum Medical Scientific Office, Lund, Sweden
Susanne H. Hoischen, Diaverum Medical Scientific Office, Lund, Sweden
Steffan Schon, Diaverum Medical Scientific Office, Lund, Sweden
Paul Stroumza, Diaverum Medical Scientific Office, Lund, Sweden
Delia Timofte, Diaverum Medical Scientific Office, Lund, Sweden
Marietta Torok, Diaverum Medical Scientific Office, Lund, Sweden
Jorgen Hegbrant, Diaverum Medical Scientific Office, Lund, Sweden
Charlotta Wollheim, Diaverum Medical Scientific Office, Lund, Sweden
Luc Frantzen, Diaverum Medical Scientific Office, Lund, Sweden
G F M Strippoli, Diaverum Medical Scientific Office, Lund, Sweden

Date of this Version

2015

Document Type

Journal Article

Publication Details

Published version

Palmer, S., C. Ruospo, M., Campbell, K. L., Garcia Larsen, V., Saglimbene, V., Natale, P., Gargano, L., Craig, J. C., Johnson, D. W.,Tonelli, M., Knight, J., Bednarek-Skublewska, A., Celia, E., del Castillo, D., Dulawa, J., Ecder, T., Fabricius, E., Frazão, J. M., Gelfman, R., Hoischen, S. H., Schön, S., Stroumza, P.,Timofte, D., Török, M., Hegbrant, J., Wollheim, C., Frantzen,L., & Strippoli, G. F. M. (2015). Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: Protocol for DIET-HD, a prospective multinational cohort study. BMJ Open, 5(3), 1-8.

Access the journal

2015 HERDC submission

© Copyright, The Authors, 2015

Distribution License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

ISSN

2044-6055

Abstract

Introduction

Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the “DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study,” a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.

Methods and analysis

DIET-HD will recruit approximately 10 000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA2LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.

Ethics and dissemination

The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.

 

This document has been peer reviewed.