Title

Age-related variations in comparative testosterone concentrations between boys with autism spectrum disorder and their typically-developing peers: A challenge to the ‘Extreme male brain’ hypothesis of ASD

Date of this Version

2016

Document Type

Journal Article

Publication Details

Citation only

Sharpley, C. F., Bitsika, V., Andronicos, N. M., & Agnew, L. L. (2016). Age-related variations in comparative testosterone concentrations between boys with autism spectrum disorder and their typically-developing peers: A challenge to the ‘Extreme male brain’ hypothesis of ASD. Journal of Developmental and Physical Disabilities, 1-15.

Access the journal

© Springer Science+Business Media New York 2016

ISSN

1056-263X

Abstract

There is some disagreement in the literature regarding the presence of elevated testosterone concentrations in boys with Autism Spectrum Disorder (ASD). To explore that disagreement, the presence of significant differences in testosterone concentrations in young males with Autism Spectrum Disorder (ASD) and normally developing controls aged 6 yr. to 17 yr. was investigated. A total of 136 young males with ASD and 48 age-matched non-ASD males contributed samples of saliva at a set time and these were assayed for testosterone concentrations. There was no significant difference in testosterone concentrations between the two entire samples. When examined at two-yearly intervals, ASD participants had significantly lower testosterone concentrations at age 12 yr. to 13 yr. and also exhibited relatively homogeneous testosterone concentrations compared to non-ASD participants. These data challenge the ‘extreme male brain’ hypothesis for ASD and suggest that ASD young males were delayed in their pubertal development and that the developmental variability expected in the wider population was not present.

This document is currently not available here.

Share

COinS
 

This document has been peer reviewed.