Project Title

Targeting metabolic and vascular health with high intensity exercise training in type 2 diabetes

Chief Investigator

Associate Professor Nathan Johnson, The University of Sydney

Description

Study: Novel Exercise Therapies for Type 2 Diabetes (HIIT Diabetes)

The location of adipose tissue, particularly in the liver, heart and skeletal muscles appears to be of greater importance than total body fat when determining clinical implications and treatment options for obesity-related disease (1). Whilst most of these “ectopic fat” depots have been extensively researched, the same cannot be said for fat found in the pancreas, which is situated underneath fat of the abdominal cavity, making in vivo studies difficult (2).

Recent advances in non-invasive imaging techniques have increased the capacity for human research on human pancreas fat (3). Emerging evidence suggests that “fatty pancreas” may contribute significantly to the underlying cardiovascular and metabolic dysfunction observed in obesity and related type 2 diabetes (4,5), including beta cell dysfunction (6,7), and that diet intervention alone or in combination with bariatric surgery, may reduce pancreas fat and improve pancreatic function (8-11).

This standard operating procedure (SOP) describes the instructions for MRI and proton magnetic resonance spectroscopy (1H-MRS) scanning for abdominal fat and pancreas fat determination for participants in the Novel Exercise Therapies for Type 2 Diabetes (HIIT Diabetes) research trial.

Keywords

Pancreas fat, Obesity, Type 2 diabetes, HIIT Diabetes, Exercise Therapy

Document Type

Research Methodology

Lead Organisation

The University of Sydney

Publication Year

2016

Distribution License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

File Format

PDF

File Size

2029 KB

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