Angela van Daal
Angela van Daal
Associate Professor
Bond University
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Association of functionally different RUNX2 P2 promoter alleles with BMD
James D Doecke, Griffith University; Christopher J. Day, Griffith University; Alexandre SJ Stephens, Griffith University; Shea L. Carter, Queensland University of Technology; Angela van Daal, Queensland University of Technology; Mark A. Kotowicz, University of Melbourne; Geoff C. Nicholson, University of Melbourne; and Nigel A. Morrison, Griffith University
DATE: February 2006
SOURCE: Journal of Bone and Mineral Research, Vol. 21, No. 2, pp. 265-273
ABOUT THIS DOCUMENT:
Doecke JD, Day CJ, Stephens AS, Carter SL, van Daal A, Kotowicz MA, Nicholson GC, Morrison NA. (2006), Association of functionally different RUNX2 P2 promoter alleles with BMD. Journal of Bone Mineral Research. Vol. 21, Iss. 2, pp. 265-73.
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Copyright ©American Society for Bone and Mineral Research, 2006.
ABSTRACT:
RUNX2 gene SNPs were genotyped in subjects from the upper and lower deciles of age- and weight-adjusted femoral neck BMD. Of 16 SNPs in RUNX2 and its two promoters (P1 and P2), only SNPs in the P2 promoter were significantly associated with BMD. These P2 promoter SNPs were functionally different in gel-shift and promoter activity assays.